Wordt geladen...

A molten globule intermediate of the Von Willebrand Factor A1 domain firmly tethers platelets under shear flow

Clinical mutations in patients diagnosed with Type 2A von Willebrand disease (vWD) have been identified that break the single disulfide bond linking N- and C-termini in the vWF A1 domain. We have modeled the effect of these mutations on the disulfide-bonded structure of A1 by reducing and carboxy-am...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Tischer, Alexander, Madde, Pranathi, Blancas-Mejia, Luis. M., Auton, Matthew
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4006108/
https://ncbi.nlm.nih.gov/pubmed/24265179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24464
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!