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DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures

DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage of primary transcripts of miRNAs (pri-miRNAs) by the Drosha nuclease, the DGCR8 protein directly binds and recognizes pri-miRNAs through a mechanism currently controversial. Our previous...

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Detalhes bibliográficos
Main Authors: Faller, Michael, Toso, Daniel, Matsunaga, Michio, Atanasov, Ivo, Senturia, Rachel, Chen, Yanqiu, Zhou, Z. Hong, Guo, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905756/
https://ncbi.nlm.nih.gov/pubmed/20558544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2111310
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