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DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures
DiGeorge critical region 8 (DGCR8) is essential for maturation of microRNAs (miRNAs) in animals. In the cleavage of primary transcripts of miRNAs (pri-miRNAs) by the Drosha nuclease, the DGCR8 protein directly binds and recognizes pri-miRNAs through a mechanism currently controversial. Our previous...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905756/ https://ncbi.nlm.nih.gov/pubmed/20558544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2111310 |
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