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Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
MicroRNAs regulate the expression of many proteins and require specific maturation steps. Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNase Drosha and its partner protein, DGCR8. Although DGCR8 is known to bind heme, the molecular role of heme in p...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700927/ https://ncbi.nlm.nih.gov/pubmed/29170488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01713-y |
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