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The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin
Canonical primary microRNA transcripts (pri-miRNAs) are characterized by a ~30-bp hairpin flanked by single-stranded regions. These pri-miRNAs are recognized and cleaved by the Microprocessor complex consisting of the Drosha nuclease and its obligate RNA-binding partner DGCR8. It is not well underst...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133150/ https://ncbi.nlm.nih.gov/pubmed/24910438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.013 |
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