Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing

The RNA-binding protein DiGeorge Critical Region 8 (DGCR8) and its partner nuclease Drosha are essential for processing of microRNA (miRNA) primary transcripts (pri-miRNAs) in animals. Previous work showed that DGCR8 forms a highly stable and active complex with ferric [Fe(III)] heme using two endog...

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Détails bibliographiques
Auteurs principaux: Barr, Ian, Smith, Aaron T., Chen, Yanqiu, Senturia, Rachel, Burstyn, Judith N., Guo, Feng
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2012
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277547/
https://ncbi.nlm.nih.gov/pubmed/22308374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114514109
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