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Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing
The RNA-binding protein DiGeorge Critical Region 8 (DGCR8) and its partner nuclease Drosha are essential for processing of microRNA (miRNA) primary transcripts (pri-miRNAs) in animals. Previous work showed that DGCR8 forms a highly stable and active complex with ferric [Fe(III)] heme using two endog...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277547/ https://ncbi.nlm.nih.gov/pubmed/22308374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114514109 |
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