Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure

AIMS: Cardiac-specific overexpression of myotrophin (myo) protein in transgenic (myo-Tg) mice results in hypertrophy at 4 weeks that progresses to heart failure (HF) by 36 weeks. Gene profiling showed that p53 expression increases as hypertrophy worsens to HF, suggesting that p53 may influence myo-i...

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Autores principales: Das, Biswajit, Young, David, Vasanji, Amit, Gupta, Sudhiranjan, Sarkar, Sagartirtha, Sen, Subha
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904660/
https://ncbi.nlm.nih.gov/pubmed/20202977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq068
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