Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6

MLL is a common target for chromosomal translocations associated with acute leukemia resulting in its fusion with a large variety of nuclear or cytoplasmic proteins that may activate its oncogenic properties by distinct but poorly understood mechanisms. The MLL-AF6 fusion gene represents the most co...

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Bibliographic Details
Main Authors: Liedtke, Michaela, Ayton, Paul M., Somervaille, Tim C. P., Smith, Kevin S., Cleary, Michael L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904581/
https://ncbi.nlm.nih.gov/pubmed/20395419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-09-243386
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