17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

The HSP90 client chaperone interaction stabilizes several important enzymes and antiapoptotic proteins, and pharmacologic inhibition of HSP90 results in rapid client protein degradation. Therefore, HSP90 inhibition is an attractive therapeutic approach when this protein is active, a phenotype common...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hertlein, Erin, Wagner, Amy J., Jones, Jeffrey, Lin, Thomas S., Maddocks, Kami J., Towns, William H., Goettl, Virginia M., Zhang, Xiaoli, Jarjoura, David, Raymond, Chelsey A., West, Derek A., Croce, Carlo M., Byrd, John C., Johnson, Amy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904580/
https://ncbi.nlm.nih.gov/pubmed/20351313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-263756
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados