Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia

Epigenetic or transcriptional silencing of important tumor suppressors has been described to contribute to cell survival and tumorigenesis in chronic lymphocytic leukemia (CLL). Using gene expression microarray analysis, we found that thousands of genes are repressed more than 2-fold in CLL compared...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Timothy L., Gupta, Nikhil, Lehman, Amy, Ruppert, Amy S., Yu, Lianbo, Oakes, Christopher C., Claus, Rainer, Plass, Christoph, Maddocks, Kami J., Andritsos, Leslie, Jones, Jeffery A., Lucas, David M., Johnson, Amy J., Byrd, John C., Hertlein, Erin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053755/
https://ncbi.nlm.nih.gov/pubmed/27107422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8760
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