17-DMAG targets the nuclear factor-κB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

The HSP90 client chaperone interaction stabilizes several important enzymes and antiapoptotic proteins, and pharmacologic inhibition of HSP90 results in rapid client protein degradation. Therefore, HSP90 inhibition is an attractive therapeutic approach when this protein is active, a phenotype common...

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Autors principals: Hertlein, Erin, Wagner, Amy J., Jones, Jeffrey, Lin, Thomas S., Maddocks, Kami J., Towns, William H., Goettl, Virginia M., Zhang, Xiaoli, Jarjoura, David, Raymond, Chelsey A., West, Derek A., Croce, Carlo M., Byrd, John C., Johnson, Amy J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904580/
https://ncbi.nlm.nih.gov/pubmed/20351313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-263756
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