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HSP90 inhibition without heat shock response

In this issue of Blood, Bhatia and colleagues describe a heat shock protein 90 (HSP90) C-terminal dimerization inhibitor with mechanistic differences that distinguish it from other clinically unsuccessful N-terminal ATPase binding compounds.(1) Can graveyard raiding of an old therapeutic target with...

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Bibliografske podrobnosti
izdano v:Blood
Glavni avtor: Byrd, John C.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053952/
https://ncbi.nlm.nih.gov/pubmed/30026301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-850271
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