Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage

HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in the growth and survival of cancer cells. HSP90 inhibitors mainly bind to the ATP binding site of HSP90 an...

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Vydáno v:Biomol Ther (Seoul)
Hlavní autoři: Park, Sangkyu, Park, Jeong-A, Jeon, Jae-Hyung, Lee, Younghee
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Society of Applied Pharmacology 2019
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720532/
https://ncbi.nlm.nih.gov/pubmed/31113013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2019.051
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