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Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells
Heat shock protein 90 (HSP90) is a molecular chaperone that supports stability of client proteins. We found that HSP90 was cleaved to 55 kDa protein after treatment with histone deacetylase (HDAC) inhibitors including suberoylanilide hydroxamic acid (SAHA) in several leukemia cell lines. We further...
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| Publicado no: | Cell Stress Chaperones |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255254/ https://ncbi.nlm.nih.gov/pubmed/25119188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-014-0533-4 |
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