Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection in mice using isogenic strains differing only in SpyCEP exp...

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Main Authors: Kurupati, Prathiba, Turner, Claire E, Tziona, Ioanna, Lawrenson, Richard A, Alam, Faraz M, Nohadani, Mahrokh, Stamp, Gordon W, Zinkernagel, Annelies S, Nizet, Victor, Edwards, Robert J, Sriskandan, Shiranee
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2010
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904501/
https://ncbi.nlm.nih.gov/pubmed/20158613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07065.x
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