Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection in mice using isogenic strains differing only in SpyCEP exp...

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Detalhes bibliográficos
Main Authors: Kurupati, Prathiba, Turner, Claire E, Tziona, Ioanna, Lawrenson, Richard A, Alam, Faraz M, Nohadani, Mahrokh, Stamp, Gordon W, Zinkernagel, Annelies S, Nizet, Victor, Edwards, Robert J, Sriskandan, Shiranee
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904501/
https://ncbi.nlm.nih.gov/pubmed/20158613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07065.x
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