Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection in mice using isogenic strains differing only in SpyCEP exp...

詳細記述

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書誌詳細
主要な著者: Kurupati, Prathiba, Turner, Claire E, Tziona, Ioanna, Lawrenson, Richard A, Alam, Faraz M, Nohadani, Mahrokh, Stamp, Gordon W, Zinkernagel, Annelies S, Nizet, Victor, Edwards, Robert J, Sriskandan, Shiranee
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Publishing Ltd 2010
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904501/
https://ncbi.nlm.nih.gov/pubmed/20158613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07065.x
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