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Emerging role of the IL-8 cleaving enzyme SpyCEP in Clinical Streptococcus pyogenes infection

Neutrophil chemoattractant IL-8 is cleaved and inactivated by the Streptococcus pyogenes cell envelope protease, SpyCEP. A range of clinical S. pyogenes strains of differing emm-type demonstrated SpyCEP activity, although transcription of the SpyCEP gene cepA differed 1000-fold between isolates. Dis...

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Autori principali: Turner, Claire E., Kurupati, Prathiba, Jones, Michael D., Edwards, Robert J., Sriskandan, Shiranee
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820315/
https://ncbi.nlm.nih.gov/pubmed/19591574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/603541
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