The IL-8 protease SpyCEP is detrimental for Group A Streptococcus host-cells interaction and biofilm formation

SpyCEP-mediated chemokine degradation translates into more efficient spreading and increased severity of invasive Group A Streptococcus (GAS) infections, due to impaired neutrophil recruitment to the site of infection. SpyCEP is markedly up-regulated in invasive as compared to colonizing GAS isolate...

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Bibliographic Details
Main Authors: Andreoni, Federica, Ogawa, Taiji, Ogawa, Mariko, Madon, Jerzy, Uchiyama, Satoshi, Schuepbach, Reto A., Zinkernagel, Annelies S.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Public Health
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090674/
https://ncbi.nlm.nih.gov/pubmed/25071751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2014.00339
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