Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection in mice using isogenic strains differing only in SpyCEP exp...

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Bibliografiske detaljer
Main Authors: Kurupati, Prathiba, Turner, Claire E, Tziona, Ioanna, Lawrenson, Richard A, Alam, Faraz M, Nohadani, Mahrokh, Stamp, Gordon W, Zinkernagel, Annelies S, Nizet, Victor, Edwards, Robert J, Sriskandan, Shiranee
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2010
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904501/
https://ncbi.nlm.nih.gov/pubmed/20158613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07065.x
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