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Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and ERK phosphorylation

Persistent postoperative pain is a very common phenomenon which severely affects the lives of patients who develop it following common surgical procedures. Opioid analgesics are of limited efficacy in the treatment of persistent pain states because of side effects including antinociceptive tolerance...

詳細記述

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書誌詳細
主要な著者: Horvath, Ryan J., Landry, Russell P., Romero-Sandoval, E. Alfonso, De Leo, Joyce A.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904400/
https://ncbi.nlm.nih.gov/pubmed/20493931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.05.030
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