Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

BACKGROUND: Cannabinoid receptor type 2 (CBR2) inhibits microglial reactivity through a molecular mechanism yet to be elucidated. We hypothesized that CBR2 activation induces an anti-inflammatory phenotype in microglia by inhibiting extracellular signal-regulated kinase (ERK) pathway, via mitogen-ac...

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Hlavní autoři: Romero-Sandoval, Edgar Alfonso, Horvath, Ryan, Landry, Russell P, DeLeo, Joyce A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704199/
https://ncbi.nlm.nih.gov/pubmed/19476641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-25
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