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Spinal Microglial and Perivascular Cell Cannabinoid Receptor Type 2 Activation Reduces Behavioral Hypersensitivity without Tolerance after Peripheral Nerve Injury

BACKGROUND: Cannabinoids induce analgesia by acting on cannabinoid receptor (CBR) types 1 and/or 2. However, central nervous system side effects and antinociceptive tolerance from CBR1 limit their clinical use. CBR2 exist on spinal glia and perivascular cells, suggesting an immunoregulatory role of...

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Hlavní autoři: Romero-Sandoval, Alfonso, Nutile-McMenemy, Nancy, DeLeo, Joyce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647363/
https://ncbi.nlm.nih.gov/pubmed/18362605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318167af74
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