The Transposase Domain Protein Metnase/SETMAR Suppresses Chromosomal Translocations

Chromosomal translocations are common in leukemia, but little is known about their mechanism. Metnase (also termed SETMAR) is a fusion of a histone methylase and transposase protein that arose specifically in primates. Transposases were thought to be extinct in primates because they would mediate de...

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Bibliografiske detaljer
Main Authors: Wray, Justin, Williamson, Elizabeth A., Chester, Sean, Farrington, Jacqueline, Sterk, Rosa, Weinstock, David M., Jasin, Maria, Lee, Suk-Hee, Nickoloff, Jac A., Hromas, Robert
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904321/
https://ncbi.nlm.nih.gov/pubmed/20620605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cancergencyto.2010.04.011
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