The leukemogenic t(8;21) fusion protein AML1-ETO controls ribosomal RNA genes and associates with nucleolar organizing regions at mitotic chromosomes

RUNX1/AML1 is required for definitive hematopoiesis and is frequently targeted by chromosomal translocation in acute myeloid leukemias (AML). The t(8;21) related AML1-ETO fusion protein blocks differentiation of myeloid progenitors. Here, we show by immunofluorescence microscopy that during interpha...

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Main Authors: Bakshi, Rachit, Zaidi, Sayyed K., Pande, Sandhya, Hassan, Mohammad Q., Young, Daniel W., Lian, Jane B., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904240/
https://ncbi.nlm.nih.gov/pubmed/19001502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.033431
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