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Computational Design of Second-Site Suppressor Mutations at Protein-Protein Interfaces
The importance of a protein-protein interaction to a signaling pathway can be established by showing that amino acid mutations that weaken the interaction disrupt signaling, and that additional mutations that rescue the interaction recover signaling. Identifying rescue mutations, often referred to a...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903445/ https://ncbi.nlm.nih.gov/pubmed/19899154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22631 |
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