C Terminus of Nucleotide Binding Domain 1 Contains Critical Features for Cystic Fibrosis Transmembrane Conductance Regulator Trafficking and Activation

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(−) channel physiologically important in fluid-transporting epithelia and pathologically relevant in several human diseases. Here, we show that mutations in the C terminus of the first nucleotide binding domain comprising the late...

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Bibliographic Details
Main Authors: Billet, Arnaud, Melin, Patricia, Jollivet, Mathilde, Mornon, Jean-Paul, Callebaut, Isabelle, Becq, Frédéric
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903390/
https://ncbi.nlm.nih.gov/pubmed/20435887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120683
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