α-Conotoxin AuIB Isomers Exhibit Distinct Inhibitory Mechanisms and Differential Sensitivity to Stoichiometry of α3β4 Nicotinic Acetylcholine Receptors

Non-native disulfide isomers of α-conotoxins are generally inactive although some unexpectedly demonstrate comparable or enhanced bioactivity. The actions of “globular” and “ribbon” isomers of α-conotoxin AuIB have been characterized on α3β4 nicotinic acetylcholine receptors (nAChRs) heterologously...

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Autors principals: Grishin, Anton A., Wang, Ching-I A., Muttenthaler, Markus, Alewood, Paul F., Lewis, Richard J., Adams, David J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903359/
https://ncbi.nlm.nih.gov/pubmed/20466726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111880
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