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On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe

In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facile access to grams of Cy5-COOH via a two-step synth...

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Detalhes bibliográficos
Publicado no:Aust J Chem
Main Authors: Muttenthaler, Markus, Nevin, Simon T, Inserra, Marco, Lewis, Richard J, Adams, David J, Alewood, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212043/
https://ncbi.nlm.nih.gov/pubmed/32394983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1071/ch19456
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