System x(c)(−) and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease of intracellular GSH has been frequently linked to pathological conditions like ischemia/reperfusion injury and degenerative diseases including diabetes, atherosclerosis, and neurodegeneration. Although...

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Autors principals: Mandal, Pankaj Kumar, Seiler, Alexander, Perisic, Tamara, Kölle, Pirkko, Banjac Canak, Ana, Förster, Heidi, Weiss, Norbert, Kremmer, Elisabeth, Lieberman, Michael W., Bannai, Shiro, Kuhlencordt, Peter, Sato, Hideyo, Bornkamm, Georg W., Conrad, Marcus
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903358/
https://ncbi.nlm.nih.gov/pubmed/20463017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121327
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