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System x(c)(−) and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency
GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease of intracellular GSH has been frequently linked to pathological conditions like ischemia/reperfusion injury and degenerative diseases including diabetes, atherosclerosis, and neurodegeneration. Although...
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| Autors principals: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903358/ https://ncbi.nlm.nih.gov/pubmed/20463017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121327 |
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