System x(c)(−) and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease of intracellular GSH has been frequently linked to pathological conditions like ischemia/reperfusion injury and degenerative diseases including diabetes, atherosclerosis, and neurodegeneration. Although...

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Bibliographische Detailangaben
Hauptverfasser: Mandal, Pankaj Kumar, Seiler, Alexander, Perisic, Tamara, Kölle, Pirkko, Banjac Canak, Ana, Förster, Heidi, Weiss, Norbert, Kremmer, Elisabeth, Lieberman, Michael W., Bannai, Shiro, Kuhlencordt, Peter, Sato, Hideyo, Bornkamm, Georg W., Conrad, Marcus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903358/
https://ncbi.nlm.nih.gov/pubmed/20463017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121327
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