System x(c)(−) and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease of intracellular GSH has been frequently linked to pathological conditions like ischemia/reperfusion injury and degenerative diseases including diabetes, atherosclerosis, and neurodegeneration. Although...

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Hlavní autoři: Mandal, Pankaj Kumar, Seiler, Alexander, Perisic, Tamara, Kölle, Pirkko, Banjac Canak, Ana, Förster, Heidi, Weiss, Norbert, Kremmer, Elisabeth, Lieberman, Michael W., Bannai, Shiro, Kuhlencordt, Peter, Sato, Hideyo, Bornkamm, Georg W., Conrad, Marcus
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903358/
https://ncbi.nlm.nih.gov/pubmed/20463017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121327
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