Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1

Three syntheses of the architecturally complex, cytotoxic marine macrolide (+)-spongistatin 1 (1) are reported. Highlights of the first-generation synthesis include: use of a dithiane multicomponent linchpin coupling tactic for construction of the AB and CD spiroketals, and their union via a highly...

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Detalhes bibliográficos
Main Authors: Smith, Amos B., Sfouggatakis, Chris, Risatti, Christina A., Sperry, Jeffrey B., Zhu, Wenyu, Doughty, Victoria A., Tomioka, Takashi, Gotchev, Dimitar B., Bennett, Clay S., Sakamoto, Satoshi, Atasoylu, Onur, Shirakami, Shohei, Bauer, David, Takeuchi, Makoto, Koyanagi, Jyunichi, Sakamoto, Yasuharu
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902791/
https://ncbi.nlm.nih.gov/pubmed/20640040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2009.04.003
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