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Gram-Scale Synthesis of (+)-Spongistatin 1. Development of An Improved, Scalable Synthesis of the F-Ring Subunit, Fragment Union, and Final Elaboration

[Image: see text] In a quest to develop an effective, scalable synthesis of (+)-spongistatin 1 (1), we devised a concise, third-generation scalable synthesis of (+)-7, the requisite F-ring tetrahydropyran aldehyde, employing a proline-catalyzed cross-aldol reaction. Subsequent elaboration to (+)-EF...

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Bibliografiset tiedot
Päätekijät: Smith, Amos B., Tomioka, Takashi, Risatti, Christina A., Sperry, Jeffrey B., Sfouggatakis, Chris
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819470/
https://ncbi.nlm.nih.gov/pubmed/18754594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol801792k
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