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Studies Toward the Synthesis of Spirolides: Assembly of the Elaborated E-Ring Fragment

A stereoselective synthesis of the spiroimine fragment of spirolide C is described. The congested C7 and C29 tertiary and quaternary centers are constructed by a diastereoselective Ireland-Claisen rearrangement. The E ring is completed by means of an aldol cyclocondensation. Additional studies were...

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Autori principali: Stivala, Craig E., Zakarian, Armen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756537/
https://ncbi.nlm.nih.gov/pubmed/19199776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8027797
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