Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability

The objective of this work was to develop a self-microemulsifying drug delivery system (SMEDDS) for improving oral absorption of poorly water-soluble drug, silymarin. The pseudo-ternary phase diagrams were constructed using ethyl linoleate, Cremophor EL, ethyl alcohol, and normal saline to identify...

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Hlavní autoři: Li, Xinru, Yuan, Quan, Huang, Yanqing, Zhou, Yanxia, Liu, Yan
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902333/
https://ncbi.nlm.nih.gov/pubmed/20405254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9432-x
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