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Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability
The objective of this work was to develop a self-microemulsifying drug delivery system (SMEDDS) for improving oral absorption of poorly water-soluble drug, silymarin. The pseudo-ternary phase diagrams were constructed using ethyl linoleate, Cremophor EL, ethyl alcohol, and normal saline to identify...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Springer US
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902333/ https://ncbi.nlm.nih.gov/pubmed/20405254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9432-x |
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