Self-microemulsifying drug delivery system for improved oral bioavailability of oleanolic acid: design and evaluation

Oleanolic acid is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) has been developed to enhance the solubility and oral bioavailability of oleanolic acid. The formulation design was optimized by solubility assay, compatibility tests, a...

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Bibliographic Details
Main Authors: Yang, Rui, Huang, Xin, Dou, Jinfeng, Zhai, Guangxi, Su, Lequn
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2013
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743642/
https://ncbi.nlm.nih.gov/pubmed/23966781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S47510
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