Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line

We previously reported that a single DNA double-strand break (DSB) near a telomere in mouse embryonic stem cells can result in chromosome instability. We have observed this same type of instability as a result of spontaneous telomere loss in human tumor cell lines, suggesting that a deficiency in th...

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Bibliographic Details
Main Authors: Zschenker, Oliver, Kulkarni, Avanti, Miller, Douglas, Reynolds, Gloria. E., Granger-Locatelli, Marine, Pottier, Géraldine, Sabatier, Laure, Murnane, John. P.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901176/
https://ncbi.nlm.nih.gov/pubmed/19540174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.05.004
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