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Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair

We have previously demonstrated that double-strand breaks (DSBs) in regions near telomeres are much more likely to result in large deletions, gross chromosome rearrangements, and chromosome instability than DSBs at interstitial sites within chromosomes. In the present study, we investigated whether...

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Autors principals: Miller, Douglas, Reynolds, Gloria E., Mejia, Ricardo, Stark, Jeremy M., Murnane, John P.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084351/
https://ncbi.nlm.nih.gov/pubmed/21466975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.03.001
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