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Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line
We previously reported that a single DNA double-strand break (DSB) near a telomere in mouse embryonic stem cells can result in chromosome instability. We have observed this same type of instability as a result of spontaneous telomere loss in human tumor cell lines, suggesting that a deficiency in th...
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| Huvudupphovsmän: | , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901176/ https://ncbi.nlm.nih.gov/pubmed/19540174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2009.05.004 |
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