Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells

Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangements associated with tumorigenesis. To determine the relationship between telomere loss and chromosome instability i...

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Detalhes bibliográficos
Main Authors: Lo, Anthony W. I., Sprung, Carl N., Fouladi, Bijan, Pedram, Mehrdad, Sabatier, Laure, Ricoul, Michelle, Reynolds, Gloria E., Murnane, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133890/
https://ncbi.nlm.nih.gov/pubmed/12052890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4836-4850.2002
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