Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells

Telomeres are essential for protecting the ends of chromosomes and preventing chromosome fusion. Telomere loss has been proposed to play an important role in the chromosomal rearrangements associated with tumorigenesis. To determine the relationship between telomere loss and chromosome instability i...

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Autors principals: Lo, Anthony W. I., Sprung, Carl N., Fouladi, Bijan, Pedram, Mehrdad, Sabatier, Laure, Ricoul, Michelle, Reynolds, Gloria E., Murnane, John P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2002
Matèries:
DNA Dynamics and Chromosome Structure
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC133890/
https://ncbi.nlm.nih.gov/pubmed/12052890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4836-4850.2002
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