Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

The transcription factor Foxp3 is essential for optimal regulatory T (T reg) cell development and function. Here, we show that CD4(+) T cells from Cbl-b RING finger mutant knockin or Cbl-b–deficient mice show impaired TGF-β–induced Foxp3 expression. These T cells display augmented Foxo3a phosphoryla...

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Hlavní autoři: Harada, Yohsuke, Harada, Yasuyo, Elly, Chris, Ying, Ge, Paik, Ji-Hye, DePinho, Ronald A., Liu, Yun-Cai
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901074/
https://ncbi.nlm.nih.gov/pubmed/20439537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100004
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