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The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

Transforming growth factor-β (TGF-β) signaling in naive T cells induces expression of the transcription factor Foxp3, a ‘master’ regulator of regulatory T cells (T(reg) cells). However, the molecular mechanisms leading to Foxp3 induction remain unclear. Here we show that Itch(−/−) T cells were resis...

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Detalhes bibliográficos
Main Authors: Venuprasad, K, Huang, Haining, Harada, Yousuke, Elly, Chris, Subramaniam, Malayannan, Spelsberg, Thomas, Su, Jin, Liu, Yun-Cai
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610020/
https://ncbi.nlm.nih.gov/pubmed/18278048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/niXXXX
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