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The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
Transforming growth factor-β (TGF-β) signaling in naive T cells induces expression of the transcription factor Foxp3, a ‘master’ regulator of regulatory T cells (T(reg) cells). However, the molecular mechanisms leading to Foxp3 induction remain unclear. Here we show that Itch(−/−) T cells were resis...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2610020/ https://ncbi.nlm.nih.gov/pubmed/18278048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/niXXXX |
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