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Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase

Cbl functions as an adaptor protein by interacting with other signalling molecules to form multimolecular complexes. Previous studies have proposed that Cbl is also a positive regulator of CrkL–C3G signalling, which leads to Rap1 activation. However, there is a lack of genetic evidence for a physiol...

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Bibliografiska uppgifter
Huvudupphovsmän: Shao, Yuan, Elly, Chris, Liu, Yun-Cai
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2003
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1319168/
https://ncbi.nlm.nih.gov/pubmed/12671687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor813
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