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Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase
Cbl functions as an adaptor protein by interacting with other signalling molecules to form multimolecular complexes. Previous studies have proposed that Cbl is also a positive regulator of CrkL–C3G signalling, which leads to Rap1 activation. However, there is a lack of genetic evidence for a physiol...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1319168/ https://ncbi.nlm.nih.gov/pubmed/12671687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor813 |
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