ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage lymphomas with recurrent chromosome 14 translocations involving the T cell receptor α/δ (Tcra/d) locus. Such translocations have been thought to result from aberrant repair of DNA double-strand breaks (DSBs) duri...

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Main Authors: Zha, Shan, Bassing, Craig H., Sanda, Takaomi, Brush, James W., Patel, Harin, Goff, Peter H., Murphy, Michael M., Tepsuporn, Suprawee, Gatti, Richard A., Look, A. Thomas, Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901073/
https://ncbi.nlm.nih.gov/pubmed/20566716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100285
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