Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency

Ataxia telangiectasia mutated (ATM) is a protein kinase and a master regulator of DNA-damage responses. Germline ATM inactivation causes ataxia-telangiectasia (A-T) syndrome with severe lymphocytopenia and greatly increased risk for T-cell lymphomas/leukemia. Both A-T and T-cell prolymphoblastic leu...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Jiang, Wenxia, Lee, Brian J., Li, Chen, Dubois, Richard L., Gostissa, Monica, Alt, Frederick W., Zha, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408291/
https://ncbi.nlm.nih.gov/pubmed/25721125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-01-622621
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