Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation

The RAG1/2 endonuclease initiates programmed DNA rearrangements in progenitor lymphocytes by generating double-strand breaks at specific recombination signal sequences. This process, known as V(D)J recombination, assembles the vastly diverse antigen receptor genes from numerous V, D, and J coding se...

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Detalhes bibliográficos
Main Authors: Giblin, William, Chatterji, Monalisa, Westfield, Gerwin, Masud, Tehmina, Theisen, Brian, Cheng, Hwei-Ling, DeVido, Jeffrey, Alt, Frederick W., Ferguson, David O., Schatz, David G., Sekiguchi, JoAnn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662642/
https://ncbi.nlm.nih.gov/pubmed/19126872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-07-165167
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