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A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis
The Artemis gene encodes a DNA nuclease that plays important roles in non-homologous end-joining (NHEJ), a major double-strand break (DSB) repair pathway in mammalian cells. NHEJ factors repair general DSBs as well as programmed breaks generated during the lymphoid-specific DNA rearrangement, V(D)J...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024049/ https://ncbi.nlm.nih.gov/pubmed/21147755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq524 |
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