Brdm2 – an aberrant hypomorphic p63 allele

Ítems similars

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• While p73 is essential, p63 is completely dispensable for the development of the central nervous system
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• Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes
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• Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells
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• E2F1 plays a direct role in Rb stabilization and p53-independent tumor suppression
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